Simultaneous Contents Determination of Chloramphenicol and Diphenhydramine Hydrochloride in Chloro-benzene Alcohol Solution by HPLC / 中国药房

OBJECTIVE:To establish a method for the simultaneous contents determination of chloramphenicol and diphenhydr-amine hydrochloride in Chlorobenzene alcohol solution. METHODS:HPLC was performed on the column of Diamonsil C with mo-bile phase of phosphate buffer-acetonitrile(66.5∶33.5,V/V)containing 0.01 mol/L sodium heptane,column temperature was 35 ℃, flow rate was 1 ml/min,detection wavelength was 258 nm for diphenhydramine hydrochloride and 277 nm for chloramphenicol, the injection volume was 10μl. RESULTS:The linear range was 34.8-139.4μg/ml for chloramphenicol(r=0.999 8)and 93.0-930.5μg/ml for diphenhydramine hydrochloride (r=0.999 8);RSDs of precision,stability and reproducibility tests were lower than 2.0%;recoveries were 97.70%-104.02%(RSD=2.2%,n=9)and 96.72%-101.72%(RSD=1.6%,n=9). CONCLUSIONS:The method is specific,accurate with good precision,and suitable for the quality control of Chlorobenzene alcohol solution.

The anti-inflammatory and analgesic effects of Shuangwu numbness-relief decoction / 实用医学杂志

Objective To explore the anti-inflammatory and analgesic effects of Shuangwu numbness-relief decoction. Methods The anti-inflammatory effect was assessed by xylene-induced mouse auricular swelling and peritoneal capillary permeability;and the analgesic effect was assessed by hot plate method and acetic acid-induced twisting method. Results Shuangwu numbness-relief decoction at moderate or high dose had a significant inhibitory effect on mouse auricular swelling, with a significant difference as compared with the control group (P<0.01);the decoction at low , moderate , or high dose group played a marked inhibitory role in the increase in mouse peritoneal capillary permeability (P<0.01). Shuangwu numbness-relief decoction at moderate or high dose effectively reduced the writhing frequency in mice (P < 0.01). The decoction at high dose increased the pain threshold in mice one hour after intragastric administration (P < 0.05), and the decoction at moderate or high dose increased the pain threshold two hours after administration (P < 0.05). Conclusions Shuangwu numbness-relief decoction has an obvious anti-inflammatory and analgesic effect.

Study on Technology of Potassium Chloride Sustained Release Tablets by Orthogonal Test / 中国药房

26%,42%,94% which according to Chinese Pharmacoeia(2005 Edition).CONCLUSIONS: The sustained-release tablets thus prepared is proper in technique and well in vitro release effect.

Necessity and Methods for Validation of Equipments of Preparations in Medical Institutions / 中国药房

OBJECTIVE: To introduce validation to the equipments of self-made preparations in medical institutions.METHODS: The necessity and difficulties for the validation of the equipments of self-made preparations in medical institutions were analyzed from aspects of the specificity of self-made preparations,the status quo of the preparation equipment as well as the requirements on the equipments etc.RESULTS: The scope and the procedures of the validation on the equipments of preparations had been presented.CONCLUSIONS: Medical institutions should adopt suitable methods,approach and validation procedures to develop corresponding validation work for equipments of preparations based on their own condition.

Application of PDCA Cycle-based Quality Control System in ISO9001Standardization of Our Department / 中国药房

OBJECTIVE:To carry out the ISO9001standard quality control system in the department of pharmacy.METHODS:The procedures and methods of PDCA cycle(Plan-Do-Check-Action)were applied to our department's ISO9001quality authentication standardization.RESULTS:The application of PDCA cycle-based ISO9001standards proved to be successful in the standardization of our department.CONCLUTION:The ISO9001quality authentication following the PDCA cycle is effective.

Immunoregulation effects of polysaccharides isolated from Octopus dollfusi on immunosuppression mice / 中国海洋药物

Objective To study the immunoregulation effect of three kinds of polysaccharides extracted from different tissues of Octopus dollfusi on immunosuppression mice.Methods Two kinds of immunosuppression mice models were built by ip,cyclophosphamide(CY) and sc.hydrocortisone(HC),respectively.The spleen and thymus were weighed and the index of the immune organs was calculated.The white blood cells were counted by automated hematologic analyzer.Results In certain concentrations(20～80 mg?kg-1),the three kinds of polysaccharides could antagonize the atrophy of spleen and thymus caused by CY and HC,and increase the weight of spleen and thymus;The polysaccharides could protect against leukocytopenia induced by CY and HC,and especially in low and middle dose.Conclusion The results suggested that three kinds of polysaccharides extracted from Octopus dollfusi have potent enhancement effect on non-specific immunity for the immunosuppression mice.

Application of Knowledge Management in Our Pharmaceutical Department / 中国药房

OBJECTIVE:To investigate the application of knowledge management in pharmaceutical department of hos-pitals.MEHTODS:Different models of knowledge management in the pharmaceutical department of our hospital were sum-marized in recent years.RESULTS:The knowledge management model in our pharmaceutical department has been shaped fundamentally.CONCLUSION:Coping capacity and creativity of pharmaceutical department have been strengthened by knowledge management.

Significance of Customers' Demand-Driven in the Management of Drug Supply Chain / 中国药房

OBJECTIVE:To facilitate a high performance operation of drug supply chain so as to provide satisfactory service for patients,the common terminal customers.METHODS:The principle of customer demand driven in drug supply chain and the significance of customer demand driven in drug supply chain management as well as the role hospitals played in the practice of the customer demand driven-based drug supply chain management were analyzed and qualitatively described.RESULTS & CONCLUSIONS:In the environment of buyers' market of drugs,as the terminal customers' envoy plenipotentiary and the best valuable clients in the drug market,hospitals play a key role in back driving drug supply chain's high performance operation.

Simultaneous Determination of Oleanolic Acid and Ursolic Acid in Hedyotis Diffusa with HPLC / 中国药房

OBJECTIVE:To develop a RP-HPLC method for simultaneous determination of oleanolic acid and ursolic acid in Hedyotis diffusa.METHODS:The optimum HPLC conditions were as follows:Nucledure C 18 column(4.6mm?150mm);mobile phase:acetonitrile-potassium phosphate,pH=7.84(45∶55);detection wavelength:220nm.RESULTS:The average recoveries of oleanolic acid and ursolic acid were(96.79?2.42)%and(97.15?2.33)%respectively.CONCLUSION:The met_ hod could detect oleanolic acid and ursolic acid in Hedyotis diffusa simultaneously.It could be used in the quality control of the herb.